AG Kübler – Lungenkreislaufforschung

Die AG befasst sich mit pulmonaler und kardiovaskulärer Physiologie und Pathophysiologie.

Sie befinden sich hier:

Pulmonale und kardiovaskuläre Physiologie & Pathophysiologie

Der Forschungsschwerpunkt der AG Kübler liegt auf dem Gebiet der translationalen Forschung im Bereich der pulmonalen und kardiovaskulären Physiologie und Pathophysiologie. Zu diesem Zweck werden Methoden und Erkenntnisse aus der Grundlagenforschung, welche auf intrazelluläre Signalwege und interzelluläre Kommunikation abzielen, auf der Ebene des intakten Organs respektive Organismus integriert. Dieser Ansatz ermöglicht es, neue grundlegende Pathomechanismen in komplexen Krankheitsmodellen wie dem akuten Lungenschaden, dem Lungenödem oder der pulmonalen Hypertonie zu identifizieren. Dieses Wissen wird dann für die Entwicklung und präklinische Erprobung neuer therapeutischer Strategien umgesetzt.

Ein besonderer methodischer Schwerpunkt der AG liegt im Einsatz intravitaler Mikroskopie- und Bildgebungs-Techniken in intakten Organen oder in vivo, die mit zell- und molekularbiologischen Techniken einerseits, sowie modernen physiologischen Messungen andererseits kombiniert werden.

Auszeichnungen

1996 J. Borges, Winner: Travel Award for the 6th World Congress for Microcirculation, Munich, 1996; awarded by the the German Soc. for Microcirculation and Vascular Biology
2002 C. Brückl, Winner: Poster Award; awarded at the 22nd Meeting of the European Society of Microcirculation, Exeter, 2002
2002 C. Moser, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Munich, 2002
2003 A. Kerem, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Munich, 2003
2004 S.M. Kaestle, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Berlin, 2004
2006 J. Yin, Winner: Poster Award; awarded at the Annual Meeting of the German Physiological Society, Munich, 2006
2006 S. M. Kaestle, Winner: Research Recognition Award of the American Physiological Society; awarded at the Conference on Physiol. Genomics and Proteomics of Lung Disease, Ft. Lauderdale 2006
2006 J. Yin, Winner: Lars-Erik Gelin Conference Travel Award for the 24th European Conference on Microcirculation, Amsterdam, 2006; awarded by the European Society for Microcirculation
2007 M. Mertens, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2007; awarded by the Assembly on Critical Care
2007 J. Yin, Winner: 2nd Poster Award; awarded at the Annual Meeting of the German Soc. of Anaesthesiology and Intensive Care Medicine, Berlin, 2007
2007 A. Tabuchi, Winner: 1st Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirc. & Vasc. Biol. and EC6, Heidelberg, 2007
2007 S. M. Kaestle, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Washington, 2007
2008 J. Hoffmann & J. Yin, Winner: 1st Presentation Award; awarded at the 11th International Congress of Cardiothoracic and Vascular Anesthesia, Berlin, 2008
2009 A. Tabuchi, Winner: 1st Basic Science Presentation Award; awarded at the University of Toronto Critical Care Medicine Research Day, Toronto, 2009
2009 J. Yin, Winner: Chinese Government Award for Outstanding Self-Financed Students Abroad; awarded by the China Scholarship Council, Ministry of Education of The People's Republic of China 2008
2009 M. Mertens, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2009; awarded by the Assembly on Respiratory Structure and Function
2010 J. Hoffmann, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Berlin, 2010
2010 L. Wang, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Anaheim, 2010
2010 A. Tabuchi, Winner: Travel Award for the 74th Annual Meeting of the Japanese Circulation Society, 2010; awarded by the Japanese Circulation Society
2010 J. Yin, Winner: Servier Award in Microcirculation of the European Society for Microcirculation; awarded at the 9th World Congress for Microcirculation, Paris, 2010
2011 J. Hoffmann, Winner: Poster Award; awarded at the 2nd Research Workshop on Pulmonary Hypertension, Bayer HealthCare, Leverkusen, 2011
2011 J. Hoffmann, Winner: Pfizer Sponsorship Award for Young Investigators in Pulmonary Hypertension; awarded at the 5th PH UP2DATE conference, Munich, 2011
2011 A. Tabuchi, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2011; awarded by the Assembly on Critical Care
2011 L. Wang, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2011; awarded by the Assembly on Pulmonary Circulation
2011 M. McVey, Winner: Postgraduate Medical Education (PGME) Award of the University of Toronto, 2011
2012 H. Yu, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, San Diego, 2012
2012 L. Wang, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded from the National Emphysema Foundation honouring Claude Lefant
2012 A. Tabuchi, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Assembly on Pulmonary Circulation
2012 H. Nickles, Winner: International Trainee Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Assembly on Critical Care
2012 J. Yin, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Research Training Centre of the Li Ka Shing Kowledge Institute, Toronto
2012 M. McVey, Winner: Presentation Award, 33rd Annual Shields Research Day, Department of Anesthesia, University of Toronto
2013 C. Tang, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Boston, 2013
2013 K. Ravindran, Winner: 2013 Life Sciences: Undergraduate Student Research Opportunity Program Award; awarded by the Dept. of Physiology, University of Toronto, 2013
2013 S. Breitling, Winner: International Trainee Travel Award for the Annual Meeting of the American Thoracic Society, 2013; awarded by the Assembly on Pulmonary Circulation
2013 M. McVey, Winner: Hynek Rothbart Award for the best oral presentation at 34th Annual Shields Research Day, Department of Anesthesia, University of Toronto
2013 M. McVey, Winner: 2013 Fellowship Joseph West Memorial Fund of the Faculty of Medicine, University of Toronto, $10,000.- CAD
2013 N. Goldenberg, Winner: 2013 Operating grant by the Physicians' Services Incorporated Foundation (PSI), $19,000.- CAD
2014 N. Goldenberg, Winner: Abstract Scholarship for the Annual Meeting of the American Thoracic Society, 2014; awarded by the Assembly on Pulmonary Circulation
2014 K.-E. Huang 2014, Winner: Undergraduate Research Award, Division of Teaching Labs Award (DTL); awarded by the University of Toronto
2014 E. Liu, Winner: 2014 Keenan Summer student fellowship; awarded by the Keenan Research Centre, Toronto
2014 N. Goldenberg, Winner: Fellowship Canadian Anaesthesiology Society, $10,000.- CAD
2014 L. Michalick, Winner: Travel Award for the Annual Experimental Biology Meeting, 2014; awarded by the GlaxoSmithKline Foundation
2014 N. Goldenberg, Winner: Presentation Award and "People´s Choice" Award, 35th Annual Shields Research Day, Department of Anesthesia, University of Toronto
2014 Sponsor/Mentor for N. Goldenberg, American Society for Anesthesiologists, Best Abstract Award 2014
2014 N. Goldenberg, Li Ka Shing Research Training Centre Trainee Travel Award, St. Michael´s, Toronto, for the attendance of the Annual Conference of the American Society of Anesthesiology, New Orleans
2014-2016 D. Zabini, Schrödinger Fellowship
2014-2016 M. McVey, Canadian Blood Services PhD Fellowship
2014-2015 N. Goldenberg, Postgraduate Research Award Joseph M. West Family Memorial Fund and Edit Steinberg Scholarship Fund
2014 N. Goldenberg, Starr Medal, Faculty of Medicine, University of Toronto
2014 L. Michalick, Fellowship, Lung Disease Research Foundation for attendance of the Munich International Autumn School 2014 and the Annual Conference of the European Respiratory Society, Munich 2014
2014 S. Breitling; Travel Award to the Symposium on Vascular and Cardiac Stiffening in Seggau, AU, 2014
2014 E. Solymosi, Robert-Koch Preis für beste Dissertation Charité 2014
2014 N. Goldenberg, Winner, Trainee Presentations, Research Training Centre, Keenan Reseach Centre
2015 H. Nickles, Hermann-Rahn Award for Excellence in Pulmonary Research of the American Physiological Society
2014 Mariana Carreira Geralde, Winner, XY Fellowship, visiting fellow from Brazil
2015 Mark McVey, Winner, RTC Trainee Travel Award of the KRC Toronto, to present at the American Thoracic Society, in Denver
2015 Mark McVey, Winner, 1st Price Josie Walther Memorial Award at the Annual Periooperative Services Research Presentation, Toronto
2015 Kuo-En Huang, Winner of the Division of Teaching Labs Award; Univ. of Toronto
2015 Mark McVey, Winner, Doctor David Behan Award for Best Poster at the University of Toronto Anesthesia Research Day, Toronto
2015 Mark McVey, Winner, 1st Poster Price, Cardiovascular Platform, University of Toronto Annual Physiology Department Research Day, Toronto
2015 Lasti Erfinanda, Showcased Abstract "Sex Differences in lung barrier regulation and acute lung injury – the role of ACE2/Ang-(1-7)/Mas axis", Assembly on Pulmonary Circulation, Annual Meeting of the American Thoracic Society, 2015
2015 Mazharul Maishan, Winner 2015-16 Ontario Graduate Scholarship, 2015
2015 Mark McVey, 2nd Price and Travel Award, Fourth Annual Research and Innovation Symposium iBEST, Angel´s Den Trainee Competition; $ 2,000.-
2016 Adri Krauszman, Usha Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, San Diego, 2016
2016 V. Srbely, Winner: Keenan Research Centre Summer Student Fellowship; awarded by St. Michael´s Hospital
2016 Victoria Srbely, Winner: 2016 Life Sciences: Undergraduate Student Research Opportunity Program Award; awarded by the Dept. of Physiology, University of Toronto, 2016
2016 Mark McVey, Varnier Canada Graduate scholarship, 2016-2019
2016 Neil Goldenberg, Winner, Marion and Early Orser Prize in Anesthesia and Sleep Sciences, University of Toronto, 2016
2016 Sarah Weidenfeld, Winner, Oral Presentation Award – Basic Science, Respirology Research Day, Department of Respirology, University of Toronto, 2016
2016 Mariana Carreira Geralde, Winner, Oral Presentation Award – Clinical Science, Respirology Research Day, Department of Respirology, University of Toronto, 2016
2016 Mazharul Maishan, Winner, Poster Award, Respirology Research Day, Department of Respirology, University of Toronto, 2016
2016 Mariana Carreira Geralde, Winner, Best Abstract - Basic and translational science, Art Slutsky Day, Interdepartmental Division of Critical Care Medicine, University of Toronto, 2016
2017 Naobuhiro Yaoita, Banyu Fellowship, Japan – 4 Mio ¥
2017 Sarah Weidenfeld, Usha Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Chicago, 2017
2017 Mark McVey, Research Recognition Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Chicago, 2017

Alumni

Postdoktoranden

Dr. med. vet. Rudi Samapati (2008-2016)

Neil Goldenberg, MD PhD (2013-2015)

Dr. rer. nat. Cécile Chupin (2012-2014)

Doktoranden (Dr. med.)

Claudia Wittenberg (2008-2015) "Inflammatorischer Stress induziert die endotheliale Transzytose in pulmonalen Kapillaren über den Signalweg der sauren Sphingomyelinase" rated summa cum laude

Hannes Ranke (2010-2011) "Die Beteiligung des Cystic fibrosis transmembrane conductance regulator, des Transient Receptor Potential Vanilloid 4 und des Connexin 40 Transmembranproteins an der Entstehung der Hypoxie induzierten pulmonalen Hypertonie am Mausmodell" rated magna cum laude

Esther Solymosi (2008-2009) "Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema " rated summa cum laude

Liming Wang (2007-2012) "Hypoxic pulmonary vasoconstriction in intact mouse lungs: new insights into cellular mechanisms and therapeutic targets" rated summa cum laude.

Jun Yin (2006-2009) " Functional relevance and regulation of Transient Receptor Potential Vanilloid 4 channel in hydrostatic lung edema" rated summa cum laude.

Ning Yin (2005-2009) "Inhaled vasodilators as a new treatment strategy in pulmonary hypertension with left heart disease" rated magna cum laude.

Alexander Kerem (2003-2008) "Pulmonary endothelial dysfunction in chronic left heart failure" rated summa cum laude.

Michael Hübler (2002-2004) "Effects of circulatory arrest in deep hypothermia on cerebral integrity: experimental studies in a neonatal pig model" rated magna cum laude.

Jörg Borges (1994-1997) "Intravital microscopic analysis of leukocyte kinetics in the pulmonary microcirculation in endotoxemia" rated magna cum laude

Doktoranden (Dr. rer. medic.)

Nils Neye (2007-2012) "Inhaliertes Stickstoff-Monoxid als neue Behandlungsstrategie im experimentell-induzierten akuten Myokardinfarkt" rated magna cum laude.

Stefanie M. Kaestle (2005-2009) "Alveolar fluid reabsorption in acute and chronic pulmonary venous hypertension" rated summa cum laude.

Doktoranden (Dr. rer. nat.)

Siegfried Breitling (2011-2015) "The mast cell – B cell axis in lung vascular remodeling and pulmonary hypertension" rated magna cum laude.

Julia Hoffmann (2005-2012) "Role of mast cells in lung vascular remodeling and pulmonary hypertension" rated magna cum laude.

Michael Mertens (2006-2010) "Acute lung injury: pathogenesis and new targets for therapeutic interventions" rated magna cum laude.

Caroline Rodrigues Alves Valois (2008-2009) "Effects of selective cell adhesion molecule blockade on transendothelial migraton of monocytes/macrophages in the murine lung following administration of DMSA-coated magnetic fluid"

Doktoranden (Dr. med. vet.)

Hannah Nickles (2010-2015) "Quantitative Analyse des Totraums unter mechanischer Beatmung" rated magna cum laude

Nadine Klein (2008-2010) "Neue Therapiekonzepte in der Behandlung des akuten Lungenschadens" rated magna cum laude

Masterarbeiten

Simon Rozowsky (2011-2013); MSc in Physiology on "The role of sodium-coupled neutral amino acid transporters in alveolar fluid homeostasis"

Hanpo Yu (2010-2012); MSc in Physiology on "Role of cystic fibrosis transmembrane conductance regulator and sphingolipids in hypoxic pulmonary vasoconstriction"