AG Kübler – Lungenkreislaufforschung

Die AG befasst sich mit pulmonaler und mikrovaskulärer Physiologie und Pathophysiologie

Sie befinden sich hier:

Pulmonale und mikrovaskuläre Physiologie & Pathophysiologie

Der Forschungsschwerpunkt der AG Kübler liegt auf dem Gebiet der translationalen Forschung im Bereich der pulmonalen und mikrovaskulären Physiologie und Pathophysiologie. Zu diesem Zweck werden Methoden und Erkenntnisse aus der Grundlagenforschung, welche auf intrazelluläre Signalwege und interzelluläre Kommunikation abzielen, auf der Ebene des intakten Organs respektive Organismus integriert. Dieser Ansatz ermöglicht es, neue grundlegende Pathomechanismen in komplexen Krankheitsmodellen wie dem akuten Lungenschaden, dem Lungenödem oder der pulmonalen Hypertonie zu identifizieren. Dieses Wissen wird dann für die Entwicklung und präklinische Erprobung neuer therapeutischer Strategien umgesetzt.

Ein besonderer methodischer Schwerpunkt der AG liegt im Einsatz intravitaler Mikroskopie- und Bildgebungs-Techniken in intakten Organen oder in vivo, die mit zell- und molekularbiologischen Techniken einerseits, sowie modernen physiologischen Messungen andererseits kombiniert werden.

Auszeichnungen

  • 1996 J. Borges, Winner: Travel Award for the 6th World Congress for Microcirculation, Munich, 1996; awarded by the the German Soc. for Microcirculation and Vascular Biology
  • 2002 C. Brückl, Winner: Poster Award; awarded at the 22nd Meeting of the European Society of Microcirculation, Exeter, 2002
  • 2002 C. Moser, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Munich, 2002
  • 2003 A. Kerem, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Munich, 2003
  • 2004 S.M. Kaestle, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Berlin, 2004
  • 2006 J. Yin, Winner: Poster Award; awarded at the Annual Meeting of the German Physiological Society, Munich, 2006
  • 2006 S. M. Kaestle, Winner: Research Recognition Award of the American Physiological Society; awarded at the Conference on Physiol. Genomics and Proteomics of Lung Disease, Ft. Lauderdale 2006
  • 2006 J. Yin, Winner: Lars-Erik Gelin Conference Travel Award for the 24th European Conference on Microcirculation, Amsterdam, 2006; awarded by the European Society for Microcirculation
  • 2007 M. Mertens, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2007; awarded by the Assembly on Critical Care
  • 2007 J. Yin, Winner: 2nd Poster Award; awarded at the Annual Meeting of the German Soc. of Anaesthesiology and Intensive Care Medicine, Berlin, 2007
  • 2007 A. Tabuchi, Winner: 1st Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirc. & Vasc. Biol. and EC6, Heidelberg, 2007
  • 2007 S. M. Kaestle, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Washington, 2007
  • 2008 J. Hoffmann & J. Yin, Winner: 1st Presentation Award; awarded at the 11th International Congress of Cardiothoracic and Vascular Anesthesia, Berlin, 2008
  • 2009 A. Tabuchi, Winner: 1st Basic Science Presentation Award; awarded at the University of Toronto Critical Care Medicine Research Day, Toronto, 2009
  • 2009 J. Yin, Winner: Chinese Government Award for Outstanding Self-Financed Students Abroad; awarded by the China Scholarship Council, Ministry of Education of The People's Republic of China 2008
  • 2009 M. Mertens, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2009; awarded by the Assembly on Respiratory Structure and Function
  • 2010 J. Hoffmann, Winner: Poster Award; awarded at the Annual Meeting of the German Soc. for Microcirculation and Vascular Biology, Berlin, 2010
  • 2010 L. Wang, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Anaheim, 2010
  • 2010 A. Tabuchi, Winner: Travel Award for the 74th Annual Meeting of the Japanese Circulation Society, 2010; awarded by the Japanese Circulation Society
  • 2010 J. Yin, Winner: Servier Award in Microcirculation of the European Society for Microcirculation; awarded at the 9th World Congress for Microcirculation, Paris, 2010
  • 2011 J. Hoffmann, Winner: Poster Award; awarded at the 2nd Research Workshop on Pulmonary Hypertension, Bayer HealthCare, Leverkusen, 2011
  • 2011 J. Hoffmann, Winner: Pfizer Sponsorship Award for Young Investigators in Pulmonary Hypertension; awarded at the 5th PH UP2DATE conference, Munich, 2011
  • 2011 A. Tabuchi, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2011; awarded by the Assembly on Critical Care
  • 2011 L. Wang, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2011; awarded by the Assembly on Pulmonary Circulation
  • 2011 M. McVey, Winner: Postgraduate Medical Education (PGME) Award of the University of Toronto, 2011
  • 2012 H. Yu, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, San Diego, 2012
  • 2012 L. Wang, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded from the National Emphysema Foundation honouring Claude Lefant
  • 2012 A. Tabuchi, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Assembly on Pulmonary Circulation
  • 2012 H. Nickles, Winner: International Trainee Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Assembly on Critical Care
  • 2012 J. Yin, Winner: Travel Award for the Annual Meeting of the American Thoracic Society, 2012; awarded by the Research Training Centre of the Li Ka Shing Kowledge Institute, Toronto
  • 2012 M. McVey, Winner: Presentation Award, 33rd Annual Shields Research Day, Department of Anesthesia, University of Toronto
  • 2013 C. Tang, Winner: Research Recognition Award of the Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Boston, 2013
  • 2013 K. Ravindran, Winner: 2013 Life Sciences: Undergraduate Student Research Opportunity Program Award; awarded by the Dept. of Physiology, University of Toronto, 2013
  • 2013 S. Breitling, Winner: International Trainee Travel Award for the Annual Meeting of the American Thoracic Society, 2013; awarded by the Assembly on Pulmonary Circulation
  • 2013 M. McVey, Winner: Hynek Rothbart Award for the best oral presentation at 34th Annual Shields Research Day, Department of Anesthesia, University of Toronto
  • 2013 M. McVey, Winner: 2013 Fellowship Joseph West Memorial Fund of the Faculty of Medicine, University of Toronto, $10,000.- CAD
  • 2013 N. Goldenberg, Winner: 2013 Operating grant by the Physicians' Services Incorporated Foundation (PSI), $19,000.- CAD
  • 2014 N. Goldenberg, Winner: Abstract Scholarship for the Annual Meeting of the American Thoracic Society, 2014; awarded by the Assembly on Pulmonary Circulation
  • 2014 K.-E. Huang 2014, Winner: Undergraduate Research Award, Division of Teaching Labs Award (DTL); awarded by the University of Toronto
  • 2014 E. Liu, Winner: 2014 Keenan Summer student fellowship; awarded by the Keenan Research Centre, Toronto
  • 2014 N. Goldenberg, Winner: Fellowship Canadian Anaesthesiology Society, $10,000.- CAD
  • 2014 L. Michalick, Winner: Travel Award for the Annual Experimental Biology Meeting, 2014; awarded by the GlaxoSmithKline Foundation
  • 2014 N. Goldenberg, Winner: Presentation Award and "People´s Choice" Award, 35th Annual Shields Research Day, Department of Anesthesia, University of Toronto
  • 2014 Sponsor/Mentor for N. Goldenberg, American Society for Anesthesiologists, Best Abstract Award 2014
  • 2014 N. Goldenberg, Li Ka Shing Research Training Centre Trainee Travel Award, St. Michael´s, Toronto, for the attendance of the Annual Conference of the American Society of Anesthesiology, New Orleans
  • 2014-2016 D. Zabini, Schrödinger Fellowship
  • 2014-2016 M. McVey, Canadian Blood Services PhD Fellowship
  • 2014-2015 N. Goldenberg, Postgraduate Research Award Joseph M. West Family Memorial Fund and Edit Steinberg Scholarship Fund
  • 2014 N. Goldenberg, Starr Medal, Faculty of Medicine, University of Toronto
  • 2014 L. Michalick, Fellowship, Lung Disease Research Foundation for attendance of the Munich International Autumn School 2014 and the Annual Conference of the European Respiratory Society, Munich 2014
  • 2014 S. Breitling; Travel Award to the Symposium on Vascular and Cardiac Stiffening in Seggau, AU, 2014
  • 2014 E. Solymosi, Robert-Koch Preis für beste Dissertation Charité 2014
  • 2014 N. Goldenberg, Winner, Trainee Presentations, Research Training Centre, Keenan Reseach Centre
  • 2015 H. Nickles, Hermann-Rahn Award for Excellence in Pulmonary Research of the American Physiological Society
  • 2014 Mariana Carreira Geralde, Winner, XY Fellowship, visiting fellow from Brazil
  • 2015 Mark McVey, Winner, RTC Trainee Travel Award of the KRC Toronto, to present at the American Thoracic Society, in Denver
  • 2015 Mark McVey, Winner, 1st Price Josie Walther Memorial Award at the Annual Periooperative Services Research Presentation, Toronto
  • 2015 Kuo-En Huang, Winner of the Division of Teaching Labs Award; Univ. of Toronto
  • 2015 Mark McVey, Winner, Doctor David Behan Award for Best Poster at the University of Toronto Anesthesia Research Day, Toronto
  • 2015 Mark McVey, Winner, 1st Poster Price, Cardiovascular Platform, University of Toronto Annual Physiology Department Research Day, Toronto
  • 2015 Lasti Erfinanda, Showcased Abstract "Sex Differences in lung barrier regulation and acute lung injury – the role of ACE2/Ang-(1-7)/Mas axis", Assembly on Pulmonary Circulation, Annual Meeting of the American Thoracic Society, 2015
  • 2015 Mazharul Maishan, Winner 2015-16 Ontario Graduate Scholarship, 2015
  • 2015 Mark McVey, 2nd Price and Travel Award, Fourth Annual Research and Innovation Symposium iBEST, Angel´s Den Trainee Competition; $ 2,000.-
  • 2016 Adri Krauszman, Usha Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, San Diego, 2016
  • 2016 V. Srbely, Winner: Keenan Research Centre Summer Student Fellowship; awarded by St. Michael´s Hospital
  • 2016 Victoria Srbely, Winner: 2016 Life Sciences: Undergraduate Student Research Opportunity Program Award; awarded by the Dept. of Physiology, University of Toronto, 2016
  • 2016 Mark McVey, Varnier Canada Graduate scholarship, 2016-2019
  • 2016 Neil Goldenberg, Winner, Marion and Early Orser Prize in Anesthesia and Sleep Sciences, University of Toronto, 2016
  • 2016 Sarah Weidenfeld, Winner, Oral Presentation Award – Basic Science, Respirology Research Day, Department of Respirology, University of Toronto, 2016
  • 2016 Mariana Carreira Geralde, Winner, Oral Presentation Award – Clinical Science, Respirology Research Day, Department of Respirology, University of Toronto, 2016
  • 2016 Mazharul Maishan, Winner, Poster Award, Respirology Research Day, Department of Respirology, University of Toronto, 2016
  • 2016 Mariana Carreira Geralde, Winner, Best Abstract - Basic and translational science, Art Slutsky Day, Interdepartmental Division of Critical Care Medicine, University of Toronto, 2016
  • 2017 Naobuhiro Yaoita, Banyu Fellowship, Japan – 4 Mio ¥
  • 2017 Sarah Weidenfeld, Usha Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Chicago, 2017
  • 2017 Mark McVey, Research Recognition Award, Respiratory Section of the American Physiological Society; awarded at the Experimental Biology Conference, Chicago, 2017

Alumni

Postdoktoranden

Dr. med. vet. Rudi Samapati (2008-2016)

Dr. rer. nat. Cécile Chupin (2012-2014)

Neil Goldenberg, MD PhD (2013-2015)

Dr. rer. nat. Diana Zabini (2014-2016)

Doktoranden (Dr. med.)

Jörg Borges (1994-1997) "Intravital microscopic analysis of leukocyte kinetics in the pulmonary microcirculation in endotoxemia" rated magna cum laude

Michael Hübler (2002-2004) "Effects of circulatory arrest in deep hypothermia on cerebral integrity: experimental studies in a neonatal pig model" rated magna cum laude.

Alexander Kerem (2003-2008) "Pulmonary endothelial dysfunction in chronic left heart failure" rated summa cum laude.

Ning Yin (2005-2009) "Inhaled vasodilators as a new treatment strategy in pulmonary hypertension with left heart disease" rated magna cum laude.

Jun Yin (2006-2009) " Functional relevance and regulation of Transient Receptor Potential Vanilloid 4 channel in hydrostatic lung edema" rated summa cum laude.

Liming Wang (2007-2012) "Hypoxic pulmonary vasoconstriction in intact mouse lungs: new insights into cellular mechanisms and therapeutic targets" rated summa cum laude.

Esther Solymosi  (2008-2009) "Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema " rated summa cum laude

Hannes Ranke (2010-2011) "Die Beteiligung des Cystic fibrosis transmembrane conductance regulator, des Transient Receptor Potential Vanilloid 4 und des Connexin 40 Transmembranproteins an der Entstehung der Hypoxie induzierten pulmonalen Hypertonie am Mausmodell" rated magna cum laude

Claudia Wittenberg (2008-2015) "Inflammatorischer Stress induziert die endotheliale Transzytose in pulmonalen Kapillaren über den Signalweg der sauren Sphingomyelinase" rated summa cum laude

Doktoranden (Dr. rer. medic.)

Stefanie M. Kaestle (2005-2009) "Alveolar fluid reabsorption in acute and chronic pulmonary venous hypertension" rated summa cum laude.

Nils Neye (2007-2012) "Inhaliertes Stickstoff-Monoxid als neue Behandlungsstrategie im experimentell-induzierten akuten Myokardinfarkt" rated magna cum laude.

Doktoranden (Dr. rer. nat.)

Michael Mertens (2006-2010) "Acute lung injury: pathogenesis  and new targets for therapeutic interventions" rated magna cum laude.

Caroline Rodrigues Alves Valois (2008-2009) "Effects of selective cell adhesion molecule blockade on transendothelial migraton of monocytes/macrophages in the murine lung following administration of DMSA-coated magnetic fluid"

Julia Hoffmann (2005-2012) "Role of mast cells in lung vascular remodeling and pulmonary hypertension" rated magna cum laude.

Siegfried Breitling (2011-2015) "The mast cell – B cell axis in lung vascular remodeling and pulmonary hypertension" rated magna cum laude.

 

Doktoranden (Dr. med. vet.)

Hannah Nickles (2010-2015) "Quantitative Analyse des Totraums unter mechanischer Beatmung" rated magna cum laude

Nadine Klein (2008-2010) "Neue Therapiekonzepte in der Behandlung des akuten Lungenschadens" rated magna cum laude

Masterarbeiten

Hanpo Yu (2010-2012); MSc in Physiology on "Role of cystic fibrosis transmembrane conductance regulator and sphingolipids in hypoxic pulmonary vasoconstriction"

Simon Rozowsky (2011-2013); MSc in Physiology on "The role of sodium-coupled neutral amino acid transporters in alveolar fluid homeostasis"

 

Summer students

Amanada Clausson (June-August 2006)

Stephanie Oberfoell (June-August 2007)

Nicole Bechard (June-August 2009)

Louis Winston (May-June 2010)

Lihua Zhai (May-August 2010)

Chengle Zhua (May-August 2011)

Krishnan Ravindran (May-August 2013)

Kuo-En Huang (May-August 2014)

Elizabeth Liu (May-August 2014)

Mike Chen (July-August 2014)

Mazin Kanuga (June-August 2014)

Elise Granton (May-August 2015)

Kevin Tran (May-August 2015)

Victoria Srbely (May-August 2015)