Testing of the thermal vapor therapy effectiveness
In this project, the effectiveness of the targeted thermal vapor ablation in comparison to standard therapies for patients with a severe emphysema is examined.
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How does the targeted thermal vapor ablation work and which benefits does it have?
In patients suffering from a severe emphysema, some lung regions are affected more than others. For a targeted therapy, the minimal-invasive thermal vapor ablation can be applied. A vapor catheter is used to emit a precise amount of heated water vapor into the affected lung region. The result is an inflammation reaction which leads to a tissue reconstruction. This triggers the desired shrinking effect of the tissue and leads to an increased air volume.
The effectiveness of this therapeutic method was shown in different studies (Shah et al. 2016; Herth et al. 2016; Snell et al. 2012):
In these studies, patients with a severe emphysema were treated with the thermal vapor ablation and then examined after three, six and 12 months. The results of lung function testing (FEV1/RV), the questionnaires, and the six-minute-walk test showed an improved lung function, exercise capacity, and an improvement of the life quality.
The targeted thermal vapor ablation is an effective alternative to surgical therapies.
Further literature
Thermal vapour ablation to reduce segmental volume in patients with severe emphysema: STEP-UP 12 month results.
Shah PL, Gompelmann D, Valipour A, McNulty WH, Eberhardt R, Grah C, Egan J, Ficker JH, Wagner M, Witt C, Liebers U, Hopkins P, Gesierich W, Phillips M, Stanzel F, Petermann C, Strange C, Snell G, Herth FJ.
Lancet Respir Med. 2016 Sep;4(9):e44-5. doi: 10.1016/S2213-2600(16)30199-0
Diesen Artikel finden Sie hier bei NCBI.
Segmental volume reduction using thermal vapour ablation in patients with severe emphysema: 6-month results of the multicentre, parallel-group, open-label, randomised controlled STEP-UP trial.
Herth FJ, Valipour A, Shah PL, Eberhardt R, Grah C, Egan J, Ficker JH, Wagner M, Witt C, Liebers U, Hopkins P, Gesierich W, Phillips M, Stanzel F, McNulty WH, Petermann C, Snell G, Gompelmann D.
Lancet Respir Med. 2016 Mar;4(3):185-93. doi: 10.1016/S2213-2600(16)00045-X